Background If trials of therapeutic interventions are to serve society's interests, they must be of high methodological quality and must satisfy moral commitments to human subjects. The authors set out to develop a clinical - trials compendium in which standards for the ethical treatment of human subjects are integrated with standards for research methods. Methods The authors rank-ordered the world's nations and chose the 31 with >700 active trials as of 24 July 2008. Governmental and other authoritative entities of the (...) 31 countries were searched, and 1004 English-language documents containing ethical and/or methodological standards for clinical trials were identified. The authors extracted standards from 144 of those: 50 designated as ‘core’, 39 addressing trials of invasive procedures and a 5% sample of the remainder. As the integrating framework for the standards we developed a coherent taxonomy encompassing all elements of a trial's stages. Findings Review of the 144 documents yielded nearly 15 000 discrete standards. After duplicates were removed, 5903 substantive standards remained, distributed in the taxonomy as follows: initiation, 1401 standards, 8 divisions; design, 1869 standards, 16 divisions; conduct, 1473 standards, 8 divisions; analysing and reporting results, 997 standards, four divisions; and post-trial standards, 168 standards, 5 divisions. Conclusions The overwhelming number of source documents and standards uncovered in this study was not anticipated beforehand and confirms the extraordinary complexity of the clinical trials enterprise. This taxonomy of multinational ethical and methodological standards may help trialists and overseers improve the quality of clinical trials, particularly given the globalisation of clinical research. (shrink)

This paper focuses on invasive therapeutic procedures, defined as procedures requiring the introduction of hands, instruments, or devices into the body via incisions or punctures of the skin or mucous membranes performed with the intent of changing the natural history of a human disease or condition for the better. Ethical and methodological concerns have been expressed about studies designed to evaluate the effects of invasive therapeutic procedures. Can such studies meet the same standards demanded of those, for example, evaluating pharmaceutical (...) agents? This paper describes a research project aimed at examining the interplay and sometimes apparent conflict between ethical standards for human research and standards for methodological rigor in trials of invasive procedures. The paper discusses how the authors plan to develop a set of consensus standards that, if met, would result in substantial and much-needed improvements in the methodological and ethical quality of such trials. (shrink)

This volume contains thirteen papers that were presented at the 2017 Annual Meeting of the Canadian Society for History and Philosophy of Mathematics/Société canadienne d’histoire et de philosophie des mathématiques, which was held at Ryerson University in Toronto. It showcases rigorously reviewed modern scholarship on an interesting variety of topics in the history and philosophy of mathematics from Ancient Greece to the twentieth century. A series of chapters all set in the eighteenth century consider topics such as John Marsh’s techniques (...) for the computation of decimal fractions, Euler’s efforts to compute the surface area of scalene cones, a little-known work by John Playfair on the practical aspects of mathematics, and Monge’s use of descriptive geometry. After a brief stop in the nineteenth century to consider the culture of research mathematics in 1860s Prussia, the book moves into the twentieth century with an examination of the historical context within which the Axiom of Choice was developed and a paper discussing Anatoly Vlasov’s adaptation of the Boltzmann equation to ionized gases. The remaining chapters deal with the philosophy of twentieth-century mathematics through topics such as an historically informed discussion of finitism and its limits; a reexamination of Mary Leng’s defenses of mathematical fictionalism through an alternative, anti-realist approach to mathematics; and a look at the reasons that mathematicians select specific problems to pursue. Written by leading scholars in the field, these papers are accessible to not only mathematicians and students of the history and philosophy of mathematics, but also anyone with a general interest in mathematics. (shrink)

Historically, market regulation has played an important role in shaping the trajectory of scientific and technological innovation in food and agriculture. However, regulators’ traditional focus on safety and efficacy may be insufficient to address more complex ethical, legal, and social implications of novel products, such as the use of nanotechnology and nanomaterials in food and agriculture. One solution might be to implement the principles of responsible innovation to challenge innovators and policymakers to better anticipate risks further upstream and be responsive (...) to societal desires and concerns, although substantial barriers to implementation persist. This paper presents stakeholder views on the relationship between regulation and RI in nano-agrifoods based on a broader U.S. stakeholder engagement study conducted in the fall of 2020. We found that participants raised key issues that incorporated all 4 pillars of RI. We also found that participants’ attitudes about the relationship between regulation and innovation informed their recommendations about the relationship between regulation and RI. These attitudes are represented in a spectrum of views, ranging from “regulation as barrier” to “regulation as driver” of innovation. We further identified implications for how each attitude might be used to operationalize RI in regulatory systems. Overall, these results suggest that just as regulation drove key innovations in the twentieth century, regulation may still have a role to play in helping to promote RI of nano-agrifoods in the twenty-first. (shrink)

In this paper I wish to comment upon the use of polemical argument in philosophy of education and education. Like Foucault, I believe that a whole morality is at stake because polemical argument obfuscates the search for truth at the expense of truth and the other’s veracity, integrity and dignity. The use of polemics is illustrated by two arguments. The first general argument is taken from an attack upon Albert Camus by the British writer Colin Wilson. The second more particular (...) example is taken from attacks in New Zealand by the State Department of Education upon the educational ideas of the novelist and educator Sylvia Ashton-Warner. Finally I discuss how polemics might be countered in education. (shrink)

Volume XVIII of the distinguished "Religious Perspectives" series, this translation of Jaspers' 1962 publication Der philosophische Glaube ansichts [[sic]] der Offenbarung is an important addition to the library of English translations of Jaspers' works. It is a lengthy work and, as is typical of Jaspers, is heavily punctuated with textual divisions and subdivisions--a procedure so exaggerated in Jaspers that it is quite distracting. The translation of E. B. Ashton, who has since translated Jaspers' three-volume major work Philosophie, is extremely (...) good, just as one would expect. Jaspers holds that there is an underlying metaphysical structure in being--the Encompassing--which eludes any final conceptual formulation. It can only be approached through "ciphers," symbols which obliquely intimate the nature of the ultimate, and which it belongs to the philosopher to read. While on the one hand Jaspers quarrels with the various religious faiths because of their tendency to take their own ciphers as final and definitive, he is on the other hand profoundly interested in the historical faiths inasmuch as they represent important and deep expressions of faith in the transcendent. In this book Jaspers seeks a rapprochement between "philosophical faith"--an idea which he has ultimately borrowed from Kant's notion of rational faith in the speculatively unknowable thing-in-itself--and the faith that is based on revelation.--J. D. C. (shrink)

Résumé La publication, en 2020, de la nouvelle de Beauvoir, désormais intitulée Les Inséparables, constitue une bonne surprise pour ses lecteur.trice.s. Jugée, en 1954, sans intérêt par son auteure (dont il faut interroger les motivations), elle se révèle passionnante pour comprendre la genèse des Mémoires d’ une jeune fille rangée, autobiographie qu’ elle annonce (sans l’ égaler). Elle intéresse également par elle-même, car elle apporte un éclairage supplémentaire sur l’ histoire tragique de Zaza, et sur l’ amitié qui l’ (...) unit à la jeune Simone. (shrink)

Les prédications eckhartiennes qui nous sont parvenues, sont au nombre d’environ 100 en latin, et de 120 en moyen haut allemand. La critique situe la plus grande partie de ces prédications allemandes dans la dernière décennie de la vie d’Eckhart. Mais son intérêt pour la prédication est présent dans son œuvre dès le début et accompagne toute sa carrière. En particulier, ce qui caractérise son travail homilétique par rapport aux maîtres en théologie, ses contemporains, semble bien être l’usage de la (...) langue vulgaire et le soin particulier apporté à la mise en forme littéraire et à la publication de ces prédications. D’où la question posée : pourquoi cet intérêt pour l’usage de la langue vulgaire? L’attention dans cette étude se concentre donc sur les prédications allemandes et à ce propos sont traités deux arguments qui paraissent particulièrement significatifs. Le premier se concentre sur la nécessité de leur recontextualisation liturgique. En effet, l’aspect liturgique a été complètement occulté dans l’édition critique et la littérature. Le second se manifeste par la nécessité d’explorer le caractère littéraire des prédications, qui ne sont pas de fait “reportées” par des auditeurs (-trices), mais ont été rédigées et publiées par les soins de l’auteur lui-même. Enfin il faut noter comme caractéristique de l’homilétique eckhartienne, le lien essentiel entre locutio emphatica et discours démonstratif (« natiurlîche rede ») : l’examen de quelques textes tirés de la Défense d’Eckhart (1326) tente d’éclairer ce concept. (shrink)

Des mobilisations massives contre « l’idéologie du genre » ont marqué les années 2010. Elles sont le point de départ de ce livre. Le succès du mouvement a pris de court les chercheur.es et acteurs/trices de la lutte pour l’égalité des sexes et l’extension des libertés individuelles en matière d’orientation sexuelle : les résistances ne se réduisent pas à quelques reliquats du passé, mais se matérialisent partout, dans une nouvelle campagne transnationale, organisée et coordonnée à large échel...

Résumé Dans cet entretien, Claudia Bouliane interroge les principaux.ales éditeur.trice.s de la Pléiade consacrée aux Mémoires de Simone de Beauvoir au sujet des choix qu’ ils ont fait quant à la manière d’ encadrer le lectorat dans sa (re)découverte des écrits autobiographiques de l’ autrice et philosophe. L’ échange s’ organise autour des différentes parties critiques des deux volumes ainsi que de l’ album et soulève des questions d’ ordre méthodologique, en plus d’ éclairer les rapports particuliers de Beauvoir (...) à l’ Histoire, à l’ identité, à l’ amitié, à l’ écriture et à la réception de ses écrits. (shrink)

En considérant la fabrique cinématographique comme une expérience politique et artistique, et un film terminé comme le lieu d’un regard singulier d’un·e cinéaste, cet article entend analyser le rapport au temps qu’entretiennent les acteurs·trices de la scène cinématographique au Liban depuis les trois dernières années. Du soulèvement de 2019 à l’année 2022, la relation au temps se caractérise par une incertitude constante qu’il convient d’explorer, avec d’une part les temporalités de la fragmentation liées au contexte du pays, et d’autre part, (...) les temporalités de la conception d’une œuvre. Comment est-ce que la temporalité de la création d’un film, souvent longue et difficile, s’imbrique-t-elle dans les multiples temporalités du pays faites d’une accumulation de crises? (shrink)

The article of Shestopalets D.V. deals with the construction of theological discourse in the publications of the Spirituals Administration of Muslims of Ukraine. Special attention is devoted to the topics that represent the “proper” image of Islam, the problem of orthodoxy, approaches to interpretation of the Quran and legitimization of the religious authority of Muslim scholars.

This paper develops the concept of ‘creative attention’. Against classical theories that understand attention as a spotlight that brings objects into focus, I will argue that attention is a complex phenomenon structured in different layers. The most basic layer is perceptual, passive and pre-predicative: at this level, attention is creative – and this is the central claim of this paper – because it institutes meanings and rules for our behaviour.

A stream of conscious experience is extremely contextual; it is impacted by sensory stimuli, drives and emotions, and the web of associations that link, directly or indirectly, the subject of experience to other elements of the individual's worldview. The contextuality of one's conscious experience both enhances and constrains the contextuality of one's behavior. Since we cannot know first-hand the conscious experience of another, it is by way of behavioral contextuality that we make judgements about whether or not, and to what (...) extent, a system is conscious. Thus we believe that a deep understanding of contextuality is vital to the study of consciousness. Methods have been developed for handling contextuality in the microworld of quantum particles. Our goal has been to investigate the extent to which these methods can be used to analyze contextuality in conscious experience. (shrink)

Fichte’s Doctrine of Science of 1811 offers a sound model for explaining the conditions of semantics in its connection with the idea of freedom. Following Wolfram Hogrebe’s suggestion that the principle of contradiction works as an archaeological semantic postulate, i.e., is the implicit condition for any sentence to be meaningful, we argue that in Fichte’s definition of the phenomenon we find such a semantic postulate at a higher genetic level than the principle of contradiction indicated by Hogrebe. Moreover, the Doctrine (...) of Science of 1811 offers an analysis of the steps through which this phenomenon displays itself – i.e. Vermögen, als, Soll – which can be understood as the conditions for establishing a meaningful sentence. Fichtes Wissenschaftslehre 1811 kann uns einen soliden Modell zur Erklärung der Entstheung von Semantik anbieten. Mein Beitrag fangt mit der Darstellung Wolfram Hogrebes Hypothese an, dass der Satz vom Widerspruch als archäologisches Bedeutungspostulat fungiert, d.h. als implizite Bedingung der Möglichkeit jeglicher bedeutenden Äußerung. Ausgehend dieser Idee Hogrebes, hier schlage ich vor, dass man im Fichtes Begriffe der Erscheinung ein genetisch höheres archäologisches Bedeutungspostulat als der Satz vom Widerspruch finden kann. Daraufhin bietet die Wissenschaftslehre 1811 einen Einsicht in alle Schritte, wodurch die Erscheinung sich entfaltet – Vermögen, Durch, Als, Soll – die wir als die entsprechende Bedingungen für die Herstellung eines bedeutungsvollen Satzes verstehen können. (shrink)

Purpose. The aim of the article is to clarify the content of the concept of culture as an explication of vitality within the philosophy of life and its further modifications in current problems of contemporary. The analysis performed standing from the point, that contrasting of nature and culture is irrelevant, since culture does not contradict natural determinants and patterns, but rather qualitatively alters them. So, are justified the idea of culture as a phenomenon that exist accordingly and in proportion to (...) nature, need to form its potential and content and not contradict the axioms and values of life. Theoretical basis. In the theoretical field of philosophy of life, the local development of the problem of culture as an explication of vitality produces grounds for analytical and prognostic activity concerning meaningful transformations in a separate historical and social horizon. The fundamental categories of culture: spirit, value, symbol, freedom, justice and harmony receive the requested content and meaning. The idea of the constancy and super-naturality of cultural universals is illusory and dangerous. The consequences of such a "non-cosmological" justification of freedom and will, and the assertion of values, that contradict the logic of life, are the global environmental, economic and social crisis of our time. Originality. The originality of the authors’ thought lies in the interpretation of the essence of culture as an explication of vitality, as a logical and natural extension of life. In this formulation of the problem of culture, the possibility of reconciling the natural, social and value determinants of human life is formed. Theorists of the philosophy of life substantiated the primacy and supremacy of the values of life over the values and meanings of culture. The position of authors position consists in the need to understand culture as an environmentally appropriate and dimensional phenomenon, the content and strategies of which are determined by a single ontology. Conclusions. The analysis let authors understand the voluntarily chaotic element of life. Culture in its philosophical analysis took on a clearer anthropomorphic dimension: the immanent logic of being in substantiating the essence and purpose of man and the value of his being localized the universe of transcendence in the concept of "living world", "inhabited space", "human, too human". Accordingly, the range of cultural evaluations has been polarized: from the approving statement of its vital essence, to the disparaging calls for its reform. The chaotic state of voluntarily acts is transformed into cultural codes and stereotypes by rationalization. The modern global nature of crisis phenomena, both in the worldview, in the social, and in the ecological dimension, requires reformatting the understanding of culture as a continuation of nature, and not its antipode. (shrink)

We present the true stages machinery and illustrate its applications to descriptive set theory. We use this machinery to provide new proofs of the Hausdorff–Kuratowski and Wadge theorems on the structure of $\mathbf {\Delta }^0_\xi $, Louveau and Saint Raymond’s separation theorem, and Louveau’s separation theorem.

I read this book shortly after rereading Confessions of a Medicine Man by Alfred Tauber. (MIT Press 1999). As both these books are concerned with searching for the meaning of medicine in a world where scientific and technical goals predominate, it was inevitable that I should compare them. What intrigued me was how two books with a similar purpose could be so different. Tauber is an American physician and philosopher whose book is a personal quest to seek out a medical (...) ethos on which to base his practice. He therefore approaches his task biographically, relating a series of stories illustrative of medical issues that he has found troublesome during his medical career. He then uses these to explore those philosophical …. (shrink)

Study on the philosophy of Cārvāka, classical Indian materialist.